Of the 6 South Carolina incumbents, only 3 were re-elected.
South Carolina switched to a general ticket for its two seats, instead of electing each one separately. Only one candidate received a majority in the 1800 election, requiring an 1801 run-off election to choose a Representative for the second seat.
| District | Incumbent | Party | First elected | Result | Candidates | ||||
|---|---|---|---|---|---|---|---|---|---|
| Thomas Pinckney | Federalist | 1797 (special) | Incumbent retired. Federalist hold. | nowrap | √ Thomas Lowndes (Federalist) 87.0%[1] Robert Simons (Democratic-Republican) 13.0% | ||||
| John Rutledge, Jr. | Federalist | 1796 | Incumbent re-elected. | nowrap | √ John Rutledge, Jr. (Federalist) 60.3% Charles J. Colcock (Democratic-Republican) 39.7% | ||||
| Benjamin Huger | Federalist | 1798 | Incumbent re-elected. | nowrap | √ Benjamin Huger (Federalist) 54.5% Lemuel Benton (Democratic-Republican) 45.1% Tristam Thomas 0.4% | ||||
| Thomas Sumter | Democratic-Republican | 1796 | Incumbent re-elected. | nowrap | √ Thomas Sumter (Democratic-Republican) 63.3% Richard Winn (Federalist) 32.6% William Bracey (Federalist) 4.1% | ||||
| Robert Goodloe Harper | Federalist | 1794 | Incumbent retired. Democratic-Republican gain. | nowrap | √ William Butler Sr. (Democratic-Republican) 63.9% John Nicholls (Federalist) 31.0% Charles Goodwyn (Federalist) 5.1% | ||||
| Abraham Nott | Federalist | 1798 | Incumbent retired. Democratic-Republican gain. | nowrap | √ Thomas Moore (Democratic-Republican) 50.7% William Smith (Democratic-Republican) 49.3% |