Of the 10 North Carolina incumbents, 8 were re-elected.
| District | Incumbent | Party | First elected | Result | Candidates | ||||
|---|---|---|---|---|---|---|---|---|---|
| Joseph Dickson | Federalist | 1798 | Incumbent lost re-election. New member elected. Democratic-Republican gain. | nowrap | √ James Holland (Democratic-Republican) 60.9% Joseph Dickson (Federalist) 38.1% | ||||
| Archibald Henderson | Federalist | 1798 | Incumbent re-elected. | nowrap | √ Archibald Henderson (Federalist) 49.3% Musendine Matthews (Federalist) 29.0% Matthew Locke (Democratic-Republican) 21.7% | ||||
| Robert Williams | Democratic-Republican | 1796 | Incumbent re-elected. | nowrap | √ Robert Williams (Democratic-Republican) 75.1% John Hamilton (Federalist) 24.9% | ||||
| Richard Stanford | Democratic-Republican | 1796 | Incumbent re-elected. | nowrap | √ Richard Stanford (Democratic-Republican) 61.6% William Strudwick (Federalist) 38.4% | ||||
| Nathaniel Macon | Democratic-Republican | 1791 | Incumbent re-elected. | nowrap | √ Nathaniel Macon (Democratic-Republican) 97.4% Scattering 2.6% | ||||
| William H. Hill | Federalist | 1798 | Incumbent re-elected. | nowrap | √ William H. Hill (Federalist) 65.2% James Gillespie (Democratic-Republican) 34.8% | ||||
| William Barry Grove | Federalist | 1791 | Incumbent re-elected. | nowrap | √ William Barry Grove (Federalist) 77.8% Samuel D. Purviance (Democratic-Republican) 22.2% | ||||
| David Stone | Federalist | 1798 | Incumbent re-elected. Winner was also elected U.S. Senator, and therefore chose not to serve in the House in the next congress. A special election was held August 6, 1801. | nowrap | √ David Stone (Federalist) John H. Jaycocks (Federalist) John White | ||||
| Willis Alston | Democratic-Republican | 1798 | Incumbent re-elected. | nowrap | √ Willis Alston (Democratic-Republican) 58.1% Thomas Blount (Democratic-Republican) 41.9% | ||||
| Richard Dobbs Spaight | Democratic-Republican | 1798 | Incumbent lost re-election. New member elected. Federalist gain. | nowrap | √ John Stanly (Federalist) 60.1% Richard Dobbs Spaight (Democratic-Republican) 39.9% |