18-Hydroxycorticosterone Explained

18-Hydroxycorticosterone is an endogenous steroid.[1] [2] It is a derivative of corticosterone.[3] [4] [5]

Function

18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa.[6] It is also an intermediate in the biosynthesis of corticosterone. It spontaneously and reversibly converts to various less polar forms and derivatives, some of which serve as precursors to aldosterone or corticosterone. Specifically, 21-hydroxy-11,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone in the presence of malate and NADP+ at pH 4.8, indicating that 18-DAL acts as a metabolic intermediate between 18-hydroxycorticosterone and aldosterone.[7] Corticosterone is a mediate precursor in this biosynthesis pathway, with 18-hydroxycorticosterone serving as an intermediate between corticosterone and aldosterone.[8]

See also

Notes and References

  1. Reddish MJ, Guengerich FP . Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone . The Journal of Biological Chemistry . 294 . 35 . 12975–12991 . August 2019 . 31296661 . 6721951 . 10.1074/jbc.RA119.009830 . free .
  2. Mulatero P, di Cella SM, Monticone S, Schiavone D, Manzo M, Mengozzi G, Rabbia F, Terzolo M, Gomez-Sanchez EP, Gomez-Sanchez CE, Veglio F . 18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes . The Journal of Clinical Endocrinology and Metabolism . 97 . 3 . 881–9 . March 2012 . 22238407 . 10.1210/jc.2011-2384 . free .
  3. Gupta V . Mineralocorticoid hypertension . Indian Journal of Endocrinology and Metabolism . 15 Suppl 4 . 8. S298–312 . October 2011 . 22145132 . 3230101 . 10.4103/2230-8210.86972 . free .
  4. Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM . Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects . The Journal of Clinical Endocrinology and Metabolism . 89 . 9 . 4628–33 . September 2004 . 15356073 . 1283128 . 10.1210/jc.2004-0379.
  5. Izumi Y . [18-Hydroxycorticosterone (18-OH-B)] . ja . Nihon Rinsho. Japanese Journal of Clinical Medicine . 68 . 348–53 . July 2010 . Suppl 7 . 20960793 .
  6. Web site: Human Metabolome Database: Showing metabocard for 18-Hydroxycorticosterone (HMDB0000319) . 2024-04-06 . 2023-06-06 . https://web.archive.org/web/20230606102731/https://hmdb.ca/metabolites/HMDB0000319 . live .
  7. Marver D . Aldosterone action in target epithelia . Vitam Horm . Vitamins & Hormones . 38 . 55–117 . 1980 . 6182690 . 10.1016/s0083-6729(08)60484-7 . 978-0-12-709838-8 .
  8. Lantos CP, Damasco MC, Aragonés A, Ceballos NR, Burton G, Cozza EN . Versatile steroid molecules at the end of the aldosterone pathway . J Steroid Biochem . 27 . 4–6 . 791–800 . 1987 . 3320559 . 10.1016/0022-4731(87)90151-8.

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