South Carolina gained one representative as a result of the 1790 census, increasing from 5 to 6.
| District | Incumbent | Party | First elected | Result | Candidates | |||
|---|---|---|---|---|---|---|---|---|
| William L. Smith | Pro-Administration | 1788 | Incumbent re-elected. | √ William L. Smith (Pro-Admin) 61.5% Thomas Tudor Tucker (Anti-Admin) 22.2% Jacob Read (Pro-Admin) 16.4% | ||||
| Thomas Tudor Tucker | Anti-Administration | 1788 | Incumbent lost re-election. Anti-Administration loss. | |||||
| None (District created) | New seat. New member elected. Anti-Administration gain. | nowrap | √ John Hunter (Anti-Admin)[1] | |||||
| None (District created) | New seat. New member elected. Anti-Administration gain. | nowrap | √ Lemuel Benton (Anti-Admin) | |||||
| None (District created) | New seat. New member elected. Anti-Administration gain. | nowrap | √ Richard Winn (Anti-Admin) | |||||
| None (District created) | New seat. New member elected. Anti-Administration gain. | nowrap | √ Alexander Gillon (Anti-Admin) | |||||
| None (District created) | New seat. New member elected. Anti-Administration gain. | nowrap | √ Andrew Pickens (Anti-Admin) | |||||