March 21 - Great New Orleans Fire (1788) kills 25% of the population and destroys 856 buildings, including St. Louis Cathedral and the Cabildo, leaving most of the town in ruins. At the time New Orleans was a Spanish colony that would be secretly given to France in 1800. Not until 1803 would New Orleans as part of the Louisiana Purchase become part of the United States.
April 13 - A riot, the Doctors' Mob, begins. Residents of Manhattan are angry about grave robbers stealing bodies for doctors to dissect. The rioting is suppressed on the 15th.