Allyltestosterone Explained

Allyltestosterone, or 17α-allyltestosterone, also known as 17α-allylandrost-4-en-17β-ol-3-one, is a steroid derived from testosterone that was first synthesized in 1936 and was never marketed.^{[1] [2]} Along with propyltestosterone (topterone), it has been patented as a topical antiandrogen and hair growth inhibitor.^[3] Allyltestosterone is the parent structure of two marketed 19-nortestosterone progestins, allylestrenol and altrenogest.^[4] These progestins are unique among testosterone derivatives in that they appear to be associated with few or no androgenic effects.^{[5] [6] [7] [8]}

See also

• Steroidal antiandrogen
• List of steroidal antiandrogens
• Allylnortestosterone
• Ethinyltestosterone
• Vinyltestosterone

Notes and References

1. Book: Allyltestosterone . Josephy E, Radt F . Elsevier's Encyclopaedia of Organic Chemistry: Series III: Carboisocyclic Condensed Compounds. https://books.google.com/books?id=HqHzCAAAQBAJ&pg=PA2653. 1 December 2013. Springer. 978-3-662-25863-7. 2653–.
2. Book: Ahluwalia GS . Management of unwanted hair . Ahluwalia G . Cosmetics Applications of Laser and Light-Based Systems. https://books.google.com/books?id=OvYSProMAiUC&pg=PA248. 16 December 2008. William Andrew. 978-0-8155-1967-6. 239–252 (248) .
3. Alteration of character of male beard growth . US . 4885289 . Breuer MM, Kaszynski EG, Shander D, Usdin VR, van der Lee H . Gillette Co LLC . 5 December 1989 . . .
4. Book: Zeelen FJ . Medicinal chemistry of steroids. 1990. Elsevier Science Limited. 978-0-444-88727-6. 108–109. Other examples are allylestrenol (42), a pro-drug converted to the 3-keto analogue (43), which is used in the treatment of threatened abortion [78,79] and altrenogest (44), used in sows and mares to suppress ovulation and estrus behaviour [80]. [...] Progestins with a 17a-allyl side chain: (42) allylestrenol, (43), (44) altrenogest..
5. Bergink EW, Loonen PB, Kloosterboer HJ . Receptor binding of allylestrenol, a progestagen of the 19-nortestosterone series without androgenic properties . Journal of Steroid Biochemistry . 23 . 2 . 165–168 . August 1985 . 3928974 . 10.1016/0022-4731(85)90232-8 .
6. Madjerek Z, De Visser J, Van Der Vies J, Overbeek GA . Allylestrenol, a pregnancy maintaining oral gestagen . Acta Endocrinologica . 35 . I . 8–19 . September 1960 . 13765069 . 10.1530/acta.0.XXXV0008 .
7. Book: Bain FT . Infectious arthritis and osteomyelitis . McKinnon AO, Squires EL, Vaala WE, Varner DD . Equine Reproduction. https://books.google.com/books?id=QPJQT6-g-YMC&pg=PT4462 . 5 July 2011. John Wiley & Sons. 978-0-470-96187-2. 457–462 .
8. Book: Committee to Review the Bureau of Land Management Wild Horse and Burro Management Program. Board on Agriculture and Natural Resources. Division on Earth and Life Studies. National Research Council . Methods and Effects of Fertility Management . Using Science to Improve the BLM Wild Horse and Burro Program: A Way Forward. https://books.google.com/books?id=0T5eAgAAQBAJ&pg=PA120. 4 October 2013. National Academies Press. 978-0-309-26494-5. 93–142 (120) .