| 16 Biggest Hits, Volume II | |
| Type: | greatest |
| Artist: | Willie Nelson |
| Cover: | Willie-Nelson-16-Biggest-Hits-Vol-2.jpg |
| Released: | August 7, 2007 |
| Genre: | Country |
| Label: | Legacy |
| Producer: | Chet Atkins, Willie Nelson, Brian Ahern, Chips Moman, Booker T. Jones |
| Prev Title: | Natural Renegade: Opus Collection |
| Prev Year: | 2007 |
| Next Title: | One Hell of a Ride |
| Next Year: | 2008 |
16 Biggest Hits, Volume II is a 2007 compilation album by country singer Willie Nelson.