16S rRNA (uracil1498-N3)-methyltransferase explained

16S rRNA (uracil^1498-N^3)-methyltransferase
Ec Number:	2.1.1.193

16S rRNA (uracil¹⁴⁹⁸-N³)-methyltransferase (DUF558 protein, YggJ, RsmE, m3U1498 specific methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (uracil¹⁴⁹⁸-N³)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + N³-methyluracil¹⁴⁹⁸ in 16S rRNA

The enzyme specifically methylates uracil¹⁴⁹⁸ at N³ in 16S rRNA.

Notes and References

1. Basturea GN, Rudd KE, Deutscher MP . Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family . RNA . 12 . 3 . 426–34 . March 2006 . 16431987 . 1383581 . 10.1261/rna.2283106 .
2. Basturea GN, Deutscher MP . Substrate specificity and properties of the Escherichia coli 16S rRNA methyltransferase, RsmE . RNA . 13 . 11 . 1969–76 . November 2007 . 17872509 . 2040091 . 10.1261/rna.700507 .