15α-Hydroxyestradiol explained

15α-Hydroxyestradiol (15α-OH-E2) is an endogenous estrogen which occurs during pregnancy.[1] [2] [3] It is structurally related to estriol (16α-hydroxyestradiol) and estetrol (15α-hydroxyestriol or 15α,16α-dihydroxyestradiol).

Notes and References

  1. Lisboa BP, Goebelsmann U, Diczfalusy E . Isolation of 15-alpha-hydroxyoestradiol from human pregnancy urine . Acta Endocrinol. . 54 . 3 . 467–72 . March 1967 . 6071364 . 10.1530/acta.0.0540467 .
  2. Jirku H, Kadner S, Levitz M . Metabolism of 15alpha-hydroxyestradiol in human pregnancy . J. Clin. Endocrinol. Metab. . 35 . 4 . 522–34 . October 1972 . 4559652 . 10.1210/jcem-35-4-522 .
  3. Lee AJ, Kosh JW, Conney AH, Zhu BT . Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5 . J. Pharmacol. Exp. Ther. . 298 . 2 . 420–32 . August 2001 . 11454902 .

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