14-Methoxydihydromorphinone Explained

14-Methoxydihydromorphinone is a semi-synthetic opioid related to 14-methoxymetopon (14-MM), an opioid with a K_i of 0.15 nM, and 14-O-methyloxymorphone (14-OMO) with a K_i of 0.10 nM. By contrast, oxymorphone has a K_i of 0.97 nM and morphine one of 6.55 nM (all at mu receptors). This suggests that both 14-OMO and 14-MM have a higher mu/kappa selectivity than oxymorphone.^{[1] [2]}

See also

• Metopon

Notes and References

1. 20600882 . In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel mu opioid analgesic with reduced propensity to alter motor function . Eur J Pharm Sci . 2010 . 41 . 1 . 125–135 . 10.1016/j.ejps.2010.05.018 . 2954314 . Spetea . M . Bohotin . CR . Asim . MF . Stübegger . K . Schmidhammer . H.
2. Book: 21630508 . Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions. Top Curr Chem . 2011 . 299 . 63–91 . Schmidhammer . H . Spetea . M. Topics in Current Chemistry. 10.1007/128_2010_77. 2011chop.book...63S. 978-3-642-18106-1.