14-Cinnamoyloxycodeinone Explained

14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs discovered in the 1960s, with over 100 times the potency of morphine.[1] It is a derivative of, being the 14-cinnamate ester.[2] In another paper, Buckett assigns the potency as 177 with a range (depending on animal and test) of 101–310×.[3] It may be of interest to researchers that the allyl group in this compound and in allylprodine overlay very closely.

See also

Notes and References

  1. Lien EJ, Tong GL, Srulevitch DB, Dias C . QSAR of narcotic analgetic agents . NIDA Research Monograph . 1978 . 22 . 186–96 . 1978 . 30907 . 2011-06-01 . dead . https://web.archive.org/web/20111015120524/http://archives.drugabuse.gov/pdf/monographs/22.pdf . 2011-10-15 .
  2. Buckett WR . Some pharmacological studies with 14-cinnamoyloxycodeinone . The Journal of Pharmacy and Pharmacology . 17 . 11 . 759–60 . November 1965 . 4379812 . 10.1111/j.2042-7158.1965.tb07602.x . 40424914 .
  3. Buckett WR . The relationship between analgesic activity, acute toxicity and chemical structure in esters of 14-hydroxycodeinone . The Journal of Pharmacy and Pharmacology . 16 . SUPPL:68–71T . December 1964 . 14265944 . 10.1111/j.2042-7158.1964.tb07539.x . 23049905 .

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