11-Dehydrothromboxane B2 Explained

11-Dehydrothromboxane B2 (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2. It is released by activated platelets and urine levels of 11-dehydro-TXB2 can be used to monitor the response to aspirin therapy when used to prevent heart disease[1] and in diseases where platelet activation is prominent.[2]

Notes and References

  1. Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J. 2007. 28. 14. 1702–1708. 10.1093/eurheartj/ehm226. 17569678. free.
  2. 10.1073/pnas.83.16.5861. 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. Catella F, Healy D, Lawson JA, FitzGerald GA. PNAS. 1986. 83. 16. 5861–5865. 3461463. 386396. 1986PNAS...83.5861C. free.

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