11-cis-retinol dehydrogenase explained

11-cis-retinol dehydrogenase
Ec Number:	1.1.1.315

11-cis-retinol dehydrogenase (RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD⁺ oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

11-cis-retinol---[retinal-binding-protein] + NAD⁺

\rightleftharpoons 11-cis-retinal---[retinol-binding-protein] + NADH + H⁺

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.

Notes and References

1. Simon A, Hellman U, Wernstedt C, Eriksson U . The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases . The Journal of Biological Chemistry . 270 . 3 . 1107–12 . January 1995 . 7836368 . 10.1074/jbc.270.3.1107 . free .
2. Wang J, Chai X, Eriksson U, Napoli JL . Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue . The Biochemical Journal . 338 (Pt 1) . 23–7 . February 1999 . 9931293 . 1220019 . 10.1042/0264-6021:3380023 .
3. Lidén M, Romert A, Tryggvason K, Persson B, Eriksson U . Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus . The Journal of Biological Chemistry . 276 . 52 . 49251–7 . December 2001 . 11675386 . 10.1074/jbc.M107337200 . free .
4. Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW . Mapping the ligand binding pocket in the cellular retinaldehyde binding protein . The Journal of Biological Chemistry . 278 . 14 . 12390–6 . April 2003 . 12536149 . 10.1074/jbc.M212775200 . free .