11-Hydroxycannabinol Explained

11-Hydroxycannabinol (11-OH-CBN) is the main active metabolite of cannabinol (CBN), one of the active components of cannabis,^[1] and has also been isolated from cannabis itself.^[2] It is more potent than CBN itself, acting as an agonist of CB₁ with around the same potency as THC, but is a weak antagonist at CB₂.^{[3] [4]}

See also

• 11-Hydroxyhexahydrocannabinol
• 11-Hydroxy-THC
• 11-Hydroxy-Delta-8-THC
• Cannabinodiol

Notes and References

1. Book: Yamamoto I, Kuzuoka K, Watanabe K, Narimatsu S, Yoshimura H . 1988 . Metabolic formation and pharmacological effects of 11-hydroxycannabinol, an active metabolite of cannabinol. . Chesher G, Consroe P, Musty R . Marihuana: an international research report. . National Campaign Against Drug Abuse, monograph series No. 7. . Australian Government Printing Office . Canberra . 135–140 .
2. ((de A Leite J)), de Oliveira MV, Conti R, ((de S Borges W)), Rosa TR, Filgueiras PR, Lacerda V, Romão W, Neto ÁC . Extraction and isolation of cannabinoids from marijuana seizures and characterization by 1H NMR allied to chemometric tools . Science & Justice . 58 . 5 . 355–365 . September 2018 . 30193661 . 10.1016/j.scijus.2018.06.005 . 52175358 .
3. Yamamoto I, Watanabe K, Kuzuoka K, Narimatsu S, Yoshimura H . The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol . Chemical & Pharmaceutical Bulletin . 35 . 5 . 2144–7 . May 1987 . 3664823 . 10.1248/cpb.35.2144 . free .
4. Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L, Breuer A, Mechoulam R . 6 . Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase . Journal of Medicinal Chemistry . 40 . 20 . 3228–33 . September 1997 . 9379442 . 10.1021/jm970126f .