11β-Methyl-19-nortestosterone dodecylcarbonate explained

11β-Methyl-19-nortestosterone 17β-dodecylcarbonate (11β-MNTDC) (developmental code name CDB-4754) is a synthetic and orally active anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was developed by the Contraceptive Development Branch (CDB) of the National Institute of Child Health and Human Development (NICHD) and has not been marketed for medical use at this time.^{[1] [2] [3] [4]} It is an androgen ester – specifically, the C17β dodecylcarbonate ester of 11β-methyl-19-nortestosterone (11β-MNT) – and acts as a prodrug of 11β-MNT in the body.

11β-MNTDC is under development as a birth control pill for men.^{[5] [6] [7]} \ It has been described as the "sister compound" of dimethandrolone undecanoate, which is also under development as a birth control pill for men.

Because 11β-MNTDC is not 5α-reduced, in contrast to testosterone, it may have less risk of scalp hair loss.^[8]

See also

• List of androgen esters § Esters of other synthetic AAS
• List of investigational sex-hormonal agents § Androgenics

Notes and References

1. Attardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA . Long-term effects of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats . Journal of Andrology . 32 . 2 . 183–192 . 2011 . 20798389 . 10.2164/jandrol.110.010371 . free .
2. Attardi BJ, Hild SA, Koduri S, Pham T, Pessaint L, Engbring J, Till B, Gropp D, Semon A, Reel JR . 6 . The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects . The Journal of Steroid Biochemistry and Molecular Biology . 122 . 4 . 212–218 . October 2010 . 20599615 . 2949447 . 10.1016/j.jsbmb.2010.06.009 .
3. Hild SA, Attardi BJ, Koduri S, Till BA, Reel JR . Effects of synthetic androgens on liver function using the rabbit as a model . Journal of Andrology . 31 . 5 . 472–481 . 2010 . 20378929 . 2943539 . 10.2164/jandrol.109.009365 .
4. Blye RP, Kim HK . U.S. Department of Health and Human Services . Nandrolone 17β-carbonates . US . 7820642 . 26 October 2010 .
5. Thirumalai A, Page ST . Recent Developments in Male Contraception . Drugs . 79 . 1 . 11–20 . January 2019 . 30588563 . 10.1007/s40265-018-1038-8 . 56895132 .
6. Web site: Second potential male birth control pill passes human safety tests.
7. Yuen F, Thirumalai A, Pham C, Swerdloff RS, Anawalt BD, Liu PY, Amory JK, Bremner WJ, Dart C, Wu H, Hull L, Blithe DL, Long J, Wang C, Page ST . Daily Oral Administration of the Novel Androgen 11β-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men . The Journal of Clinical Endocrinology and Metabolism . 105 . 3 . e835–e847 . March 2020 . 31976519 . 7049261 . 10.1210/clinem/dgaa032 .
8. Book: Shapiro LJ, Shapiro DB . Low Anabolic Profile in Assessing a Patient's Overall Hair Loss. 2018. 687–698. 10.1007/978-4-431-56547-5_72. 978-4-431-56545-1.