11β-Hydroxyandrostenedione explained

11β-Hydroxyandrostenedione (11β-OHA4), also known as 11β-hydroxyandrost-4-ene-3,17-dione, is an endogenous, naturally occurring steroid and androgen prohormone that is produced primarily, if not exclusively, in the adrenal glands.^[1] It is closely related to adrenosterone (11-ketoandrostenedione; 11-KA4), 11-ketotestosterone (11-KT), and 11-ketodihydrotestosterone (11-KDHT), which are also produced in the adrenal glands.

It can be used as a biomarker for guiding primary aldosteronism subtyping in adrenal vein sampling where blood samples are taken from both adrenal glands to compare the amount of hormone made by each gland.^[2]

See also

• 4-Androstenedione

Notes and References

1. Pretorius. Elzette. Arlt. Wiebke. Storbeck. Karl-Heinz. A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids. Molecular and Cellular Endocrinology. 441. 76–85. 2016. 0303-7207. 10.1016/j.mce.2016.08.014. 27519632. 4079662.
2. 31786984 . 2020 . Turcu . A. F. . Wannachalee . T. . Tsodikov . A. . Nanba . A. T. . Ren . J. . Shields . J. J. . O'Day . P. J. . Giacherio . D. . Rainey . W. E. . Auchus . R. J. . Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping . Hypertension . 75 . 1 . 183–192 . 10.1161/HYPERTENSIONAHA.119.13866 . 7034384 .