1-phosphatidylinositol 4-kinase explained

1-phosphatidylinositol 4-kinase
Ec Number:	2.7.1.67
Cas Number:	37205-54-2
Go Code:	0004430
Width:	270

In enzymology, a 1-phosphatidylinositol 4-kinase is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol

\rightleftharpoons ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, the structure has only been solved for this enzyme. Part of the enzyme was crystallized with its activating partner frequenin.^[1]

References

• Colodzin M, Kennedy EP . 1965 . Biosynthesis of diphosphoinositide in brain . J. Biol. Chem. . 240 . 3771 - 80 . 4284712 . 10 .
• Kai M, White GL, Hawthorne JN . 1966 . The phosphatidylinositol kinase of rat brain . Biochem. J. . 101 . 328 - 37 . 4290722 . 2 . 10.1042/bj1010328 . 1270113 .
• Walker DH, Dougherty N, Pike LJ . 1988 . Purification and characterization of a phosphatidylinositol kinase from A431 cells . Biochemistry . 27 . 6504 - 11 . 2851325 . 10.1021/bi00417a046 . 17 .
• Whitman M, Downes CP, Keeler M, Keller T, Cantley L . 1988 . Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate . Nature . 332 . 644 - 6 . 2833705 . 10.1038/332644a0 . 6165 . 1988Natur.332..644W . 4326568 .
• Barylko B . 2001 . A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans . J. Biol. Chem. . 276 . 7705 - 8 . 11244087 . 10.1074/jbc.C000861200 . Gerber . SH . Binns . DD . Grichine . N . Khvotchev . M . Südhof . TC . Albanesi . JP . 11 . free .

Notes and References

1. Strahl T . Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1) . J. Biol. Chem. . 282 . 42 . 30949–59 . 17720810 . 10.1074/jbc.M705499200 . vanc . Huttner IG . Lusin JD . 3 . Osawa . M. . King . D. . Thorner . J. . Ames . J. B.. October 2007. free .