1-Naphthoic acid explained

1-Naphthoic acid is an organic compound with the formula C₁₀H₇CO₂H. It is one of two isomeric monocarboxylic acids of naphthalene, the other one being 2-naphthoic acid. In general the hydroxynaphthoic acids are more widly use than the parent naphthoic acids.

Synthesis and reactions

1-Naphthoic acid can be prepared by carboxylation of the Grignard reagent generated from 1-bromonaphthalene.^[1]

1-Naphthoic acid is a substrate for C-H activation reactions.^[2] I

See also

• Hydroxynaphthoic acids
• Classes of synthetic cannabinoids
  • Naphthoylindoles, or 3-(1-naphthoyl)indoles
  • Naphthoylpyrroles, or 3-(1-naphthoyl)pyrroles
• Natural products containing 1-naphthoic acid moiety
  • Neocarzinostatin (as 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)
  • Azinomycin B (as 3-methoxy-5-methyl-1-naphthoate)

Notes and References

1. 10.15227/orgsyn.011.0080. α-Naphthoic Acid. Organic Syntheses. 1931. 11. 80. Henry. Gilman. Nina B.. St. John. F.. Schulze..
2. 10.1021/jo200509m. Rhodium-Catalyzed Regioselective Olefination Directed by a Carboxylic Group. 2011. Mochida. Satoshi. Hirano. Koji. Satoh. Tetsuya. Miura. Masahiro. The Journal of Organic Chemistry. 76. 9. 3024–3033. 21438629.