1-Methylcytosine Explained

1-Methylcytosine is a methylated form of the DNA base cytosine.

In 1-methylcytosine, a methyl group is attached to the 1st atom in the 6-atom ring. This methyl group distinguishes 1-methylcytosine from cytosine.

History

Miriam Rossi worked on the refinement of 1-methylcytosine.[1]

1-Methylcytosine is used as a nucleobase of hachimoji DNA, in which it pairs with isoguanine.[2]

Notes and References

  1. Kistenmacher. T. J.. Rossi. M.. 1977-12-15. 1-Methylcytosine: a refinement. Acta Crystallographica Section B. 33. 12. 3962–3965. 10.1107/S0567740877012618. 1977AcCrB..33.3962R . 0567-7408.
  2. Hoshika. Shuichi. etal. 22 February 2019. Hachimoji DNA and RNA: A genetic system with eight building blocks . Science. 363. 6429. 884–887. 10.1126/science.aat0971. 30792304. 6413494. 2019Sci...363..884H .

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