1-Deoxypentalenic acid 11beta-hydroxylase explained

1-deoxypentalenic acid 11beta-hydroxylase
Ec Number:1.14.11.35

1-deoxypentalenic acid 11beta-hydroxylase (PTLH (gene), SAV2991 (gene), PNTH (gene)) is an enzyme with systematic name 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase.[1] [2] This enzyme catalyses the following chemical reaction

1-deoxypentalenate + 2-oxoglutarate + O2

\rightleftharpoons

1-deoxy-11beta-hydroxypentalenate + succinate + CO2

1-Deoxypentalenic acid 11beta-hydroxylase contains Fe(II) and ascorbate.

Notes and References

  1. You Z, Omura S, Ikeda H, Cane DE . Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis . Journal of the American Chemical Society . 128 . 20 . 6566–7 . May 2006 . 16704250 . 2533727 . 10.1021/ja061469i .
  2. You Z, Omura S, Ikeda H, Cane DE, Jogl G . Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis . The Journal of Biological Chemistry . 282 . 50 . 36552–60 . December 2007 . 17942405 . 3010413 . 10.1074/jbc.M706358200 . free .

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