1-Deoxy-D-xylulose 5-phosphate explained

1-Deoxy--xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.

Function

The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase.^[1] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.^[2] In addition, the molecule is involved in making thiamine (Vitamin B1) and pyridoxol (Vitamin B6).

The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.^[3]

See also

• DXP synthase
• DXP reductoisomerase

Notes and References

1. Xiang . Song . Usunow . Gerlinde . Lange . Gudrun . Busch . Marco . Tong . Liang . January 2007 . Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis . Journal of Biological Chemistry . en . 282 . 4 . 2676–2682 . 10.1074/jbc.M610235200. free .
2. Bartee . David . Freel Meyers . Caren L. . 2018-07-24 . Targeting the Unique Mechanism of Bacterial 1-Deoxy- d -xylulose-5-phosphate Synthase . Biochemistry . en . 57 . 29 . 4349–4356 . 10.1021/acs.biochem.8b00548 . 29944345 . 6057799 . 0006-2960.
3. Bartee D, Freel Meyers CL . Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism . Accounts of Chemical Research . 51 . 10 . 2546–2555 . October 2018 . 30203647 . 6309272 . 10.1021/acs.accounts.8b00321 .