| 1-pyrroline-5-carboxylate dehydrogenase | |
| Ec Number: | 1.2.1.88 |
| Cas Number: | 9054-82-4 |
| Go Code: | 0003842 |
In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase is an enzyme that catalyzes the chemical reaction
(S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O
\rightleftharpoons
The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,, and .
In human, the protein is encoded by ALDH4A1 gene.