1-Octacosanol Explained

1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent.[1] Octacosanol also occurs in wheat germ.[2]

Chemistry

Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform.

Biological effects

Octacosanol is the main component in the mixture policosanol.[3] Octacosanol has been subject to preliminary study for its potential benefit for patients with Parkinson's disease.[4] [5] Studies have also found that octacosanol may inhibit the production of cholesterol.[3] In mice, octacosanol reduces stress and restores stress-affected sleep back to normal.[6]

Notes and References

  1. EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp. 139–165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London.
  2. Web site: Octacosanol . Natural Products (Professional) . drugs.com . isolated from wheat germ oil or other plants . 9 July 2009 . https://web.archive.org/web/20090603230755/http://www.drugs.com/npp/octacosanol.html . 3 June 2009 . live.
  3. 10.1016/S0899-9007(02)00869-9 . Octacosanol in human health . 2003 . Taylor . Johanna C . Rapport . Lisa . Lockwood . G.Brian . Nutrition . 19 . 2 . 192–5 . 12591561.
  4. 6395790 . 1984 . Snider . SR . Octacosanol in parkinsonism . 16 . 6 . 723 . 10.1002/ana.410160615 . Annals of Neurology. 43313071 .
  5. 20581854 . 2010 . Wang . T . Liu . YY . Wang . X . Yang . N . Zhu . HB . Zuo . PP . Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling . 31 . 7 . 765–74 . 10.1038/aps.2010.69 . Acta Pharmacologica Sinica. 4007727 .
  6. Kaushik . MK . Aritake . K . Takeuchi . A . Yanagisawa . M . Urade . Y. Octacosanol restores stress-affected sleep in mice by alleviating stress. Scientific Reports. 21 August 2017. 7. 1 . 8892 . 10.1038/s41598-017-08874-2. 28827687 . 5566941 . 2017NatSR...7.8892K .

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