1-Indanone Explained

1-Indanone is the organic compound with the formula C6H4(CH2)2CO. It is one of two isomeric benzocyclopentanones, the other being 2-indanone. It is a colorless solid. 1-Indanone is a substrate for the enzyme indanol dehydrogenase.

Preparation

It is prepared by oxidation of indane or indene.[1] It can also be prepared by cyclization of phenylpropionic acid.

300px

List of Drugs

  1. 2-Aminoindan synthesis (MDAI methodology using beta-keto-oxime formation with isoamylnitrite followed by reduction)
  2. Drinidene
  3. LNK-121[2]
  4. Pirandamine
  5. Pyrophendane
  6. SKF Derivatives[3] [4]
  7. Indane analog of nisoxetine or Prozac.[5]

Notes and References

  1. α-Hydroindone. R. A. Pacaud, C. F. H. Allen. Org. Synth.. 1938. 18. 47. 10.15227/orgsyn.018.0047.
  2. Peter T. Lansbury, Jr. Craig J. Justman, US20100292292 (2010 to Link Medicine Corp)
  3. Ganellin, C. R.; Loynes, J. M.; Ridley, H. F.; Spickett, R. G. W. (1967). "Compounds Affecting the Central Nervous System. IV. Substituted 2-Benzyl-3-dialkylaminoalkylindenes and Related Compounds". Journal of Medicinal Chemistry. 10 (5): 826–833. doi:10.1021/jm00317a016.
  4. Jack David, Spickett Robert Geoffr William & Ganellin Charon Robin, (1964 to Smith Kline and French Laboratories Ltd).
  5. Jules Freedman, (1992 to Aventis Inc)

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "1-Indanone".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.