1-Hydroxycarotenoid 3,4-desaturase explained

1-hydroxycarotenoid 3,4-desaturase
Ec Number:	1.3.99.27

1-Hydroxycarotenoid 3,4-desaturase (CrtD, hydroxyneurosporene desaturase, carotenoid 3,4-dehydrogenase, 1-hydroxy-carotenoid 3,4-dehydrogenase) is an enzyme with systematic name 1-hydroxy-1,2-dihydrolycopene:acceptor oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

1-hydroxy-1,2-dihydrolycopene + acceptor

\rightleftharpoons 1-hydroxy-3,4-didehydro-1,2-dihydrolycopene + reduced acceptor

The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides acts primarily on acyclic carotenoids.

Notes and References

1. Teramoto M, Rählert N, Misawa N, Sandmann G . 1-Hydroxy monocyclic carotenoid 3,4-dehydrogenase from a marine bacterium that produces myxol . FEBS Letters . 570 . 1-3 . 184–8 . July 2004 . 15251462 . 10.1016/j.febslet.2004.05.085 . free .
2. Steiger S, Astier C, Sandmann G . Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin . The Biochemical Journal . 349 . Pt 2 . 635–40 . July 2000 . 10880364 . 1221188 . 10.1042/0264-6021:3490635 .
3. Albrecht M, Ruther A, Sandmann G . Purification and biochemical characterization of a hydroxyneurosporene desaturase involved in the biosynthetic pathway of the carotenoid spheroidene in Rhodobacter sphaeroides . Journal of Bacteriology . 179 . 23 . 7462–7 . December 1997 . 9393712 . 179698 .