1-Amino-5-phosphonoindan-1-carboxylic acid explained
1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) is a drug that is used in neuroscience research. It is a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and has been useful in the study of this receptor subfamily.[1] [2] [3] [4] [5]
Notes and References
- Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT . Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. . Bioorganic & Medicinal Chemistry Letters . May 1997 . 7 . 9 . 1195–1198 . 10.1016/S0960-894X(97)00177-7 . free .
- Ma D, Tian H, Zou G . Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors . The Journal of Organic Chemistry . 64 . 1 . 120–125 . January 1999 . 11674092 . 10.1021/jo981297a .
- Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW . Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens . The Journal of Pharmacology and Experimental Therapeutics . 300 . 1 . 162–71 . January 2002 . 11752112 . 10.1124/jpet.300.1.162 .
- Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW . The origin and neuronal function of in vivo nonsynaptic glutamate . The Journal of Neuroscience . 22 . 20 . 9134–41 . October 2002 . 12388621 . 6757683 . 10.1523/JNEUROSCI.22-20-09134.2002 .
- Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G . Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake . Journal of Neuroscience Research . 84 . 2 . 268–77 . August 2006 . 16752416 . 10.1002/jnr.20897 . 44863411 .
