1,8-Naphthyridine Explained

1,8-Naphthyridine is an organic compound with the formula C₈H₆N₂. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings.^{[1] [2]} Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.^[3]

Coordination chemistry

With flanking nitrogen centers, 1,8-naphthyridine serves as a binucleating ligand in coordination chemistry.^{[4] [5]}

Notes and References

1. 10.1070/RC2000v069n03ABEH000553. 2000RuCRv..69..201L. Naphthyridines. Structure, Physicochemical Properties and General Methods of Synthesis. 2000. Litvinov. Victor P.. Roman. Sergey V.. Dyachenko. Vladimir D.. Russian Chemical Reviews. 69. 3. 201–220. 250827396 .
2. 10.1107/S0108270184006144. Low-Temperature (163 K) Structure of 1,8-Naphthyridine, C₈H₆N₂. 1984. Dapporto. P.. Ghilardi. C. A.. Mealli. C.. Orlandini. A.. Pacinotti. S.. Acta Crystallographica Section C Crystal Structure Communications. 40. 5. 891–894.
3. Book: Advances in Heterocyclic Chemistry. Advances in the Chemistry of Naphthyridines. V. P. Litvinov. 2006. 189–300. 91. 10.1016/S0065-2725(06)91004-6. 9780120207916.
4. 10.1039/b923125k. 20372713. Probing the electronic communication of linear heptanickel and nonanickel string complexes by utilizing two redox-active [Ni2(napy)4]3+ moieties. 2010. Hua. Shao-An. Liu. Isiah Po-Chun. Hasanov. Hasan. Huang. Gin-Chen. Ismayilov. Rayyat Huseyn. Chiu. Chien-Lan. Yeh. Chen-Yu. Lee. Gene-Hsiang. Peng. Shie-Ming. Dalton Transactions. 39. 16. 3890–6.
5. 10.1002/ejic.200900312. 1,8-Naphthyridine Revisited: Applications in Dimetal Chemistry. 2009. Bera. Jitendra K.. Sadhukhan. Nabanita. Majumdar. Moumita. European Journal of Inorganic Chemistry. 2009. 27. 4023–4038.