1,8-Cineole 2-exo-monooxygenase explained

1,8-Cineole 2-exo-monooxygenase
Ec Number:	1.14.13.157

1,8-Cineole 2-exo-monooxygenase (CYP3A4) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

1,8-cineole + NADPH + H⁺ + O₂

\rightleftharpoons 2-exo-hydroxy-1,8-cineole + NADP⁺ + H₂O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

Notes and References

1. Miyazawa M, Shindo M, Shimada T . Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes . Drug Metabolism and Disposition . 29 . 2 . 200–5 . February 2001 . 11159812 .
2. Miyazawa M, Shindo M . Biotransformation of 1,8-cineole by human liver microsomes . Natural Product Letters . 15 . 1 . 49–53 . 2001 . 11547423 . 10.1080/10575630108041257 .
3. Miyazawa M, Shindo M, Shimada T . Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes . Xenobiotica; The Fate of Foreign Compounds in Biological Systems . 31 . 10 . 713–23 . October 2001 . 11695850 . 10.1080/00498250110065595 .