1,5-anhydro-D-fructose reductase explained

1,5-anhydro-D-fructose reductase
Ec Number:	1.1.1.263
Cas Number:	206138-19-4
Go Code:	0050571

In enzymology, a 1,5-anhydro-D-fructose reductase is an enzyme that catalyzes the chemical reaction

1,5-anhydro-D-glucitol + NADP

\rightleftharpoons 1,5-anhydro-D-fructose + NADPH + H

Thus, the two substrates of this enzyme are 1,5-anhydro-D-glucitol and NADP, whereas its 3 products are 1,5-anhydro-D-fructose, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP oxidoreductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Sakuma M, Kametani S, Akanuma H . Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose . Journal of Biochemistry . 123 . 1 . 189–93 . January 1998 . 9504428 . 10.1093/oxfordjournals.jbchem.a021909 .