1,5-anhydro-D-fructose dehydratase explained

1,5-anhydro-D-fructose dehydratase
Ec Number:	4.2.1.111

The enzyme 1,5-anhydro-D-fructose dehydratase catalyzes the chemical reaction

1,5-anhydro-D-fructose

\rightleftharpoons 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + HO

It catalyzes two steps in the anhydrofructose pathway process.^[1]

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming). Other names in common use include 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydrolyase, 1,5-anhydro-D-arabino-hex-2-ulose dehydratase, AFDH, AF dehydratase, and 1,5-anhydro-D-fructose hydro-lyase.

References

• Yu S, Refdahl C, Lundt I . 2004 . Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma . Biochim. Biophys. Acta . 1672 . 120 - 9 . 15110094 . 2 . 10.1016/j.bbagen.2004.03.004 .
• Yu S, Fiskesund R . 2006 . The anhydrofructose pathway and its possible role in stress response and signaling . Biochim. Biophys. Acta . 1760 . 1314 - 22 . 16822618 . 9 . 10.1016/j.bbagen.2006.05.007 .
• Yu S . 2005 . Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate . Biochim. Biophys. Acta . 1723 . 63 - 73 . 15716041 . 1–3 . 10.1016/j.bbagen.2005.01.004 .

See also

• Anhydrofructose pathway
• Ascopyrone tautomerase
• exo-(1→4)-α-D-glucan lyase

Notes and References

1. IUBMB - Anhydrofructose Pathway