1,4-dihydroxy-2-naphthoyl-CoA hydrolase explained

1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Ec Number:	3.1.2.28

The enzyme 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28; systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase) catalyses the following reaction:^{[1] [2] [3]}

1,4-dihydroxy-2-naphthoyl-CoA + H₂O

\rightleftharpoons 1,4-dihydroxy-2-naphthoate + CoA

This enzyme participates in the biosynthesis of menaquinones,, and several plant pigments.

Notes and References

1. A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K₁ . Widhalm, J.R. . van Oostende, C. . Furt, F. . Basset, G.J. . Proc. Natl. Acad. Sci. USA . 2009 . 106 . 14 . 5599–5603 . 19321747 . 10.1073/pnas.0900738106 . 2660889. 2009PNAS..106.5599W . free .
2. 1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis . Muller, W . Leistner, E . Phytochemistry . 1976 . 15 . 3 . 407–410 . 10.1016/s0031-9422(00)86833-8.
3. Quantitative assessment of metabolic flux by ¹³C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum . Eichinger D, Bacher A, Zenk MH, Eisenreich W . J. Am. Chem. Soc. . 1999 . 121 . 33 . 7469–7475 . 10.1021/ja990622o.