1,3-Dichloropropan-2-ol explained

1,3-Dichloropropan-2-ol (1,3-DCP) is an organic compound with the formula HOCH₂CHClCH₂Cl. It is a colorless liquid. It is an intermediate in the production of epichlorohydrin.^{[1] [2]}

1,3-DCP is a believed to be a carcinogen and mutagen.^[3] The International Agency for Research on Cancer classifies it as a Group 2B carcinogen ("possibly carcinogenic to humans").^[4]

Along with 3-monochloropropane-1,2-diol (3-MCPD), 1,3-DCP is found in some Asian style sauces such as soy sauce and oyster sauce.^{[5] [6] [7]}

Notes and References

1. Book: Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-Water . 1,3-Dichloro-2-propanol . 2013 . International Agency for Research on Cancer .
2. 10.1021/es903383a. 20163179. Identifying New Persistent and Bioaccumulative Organics Among Chemicals in Commerce. Environmental Science & Technology. 44. 7. 2277–2285. 2010. Howard. Philip H.. Muir. Derek C. G.. 2010EnST...44.2277H. free.
3. Web site: Evidence on the Carcinogenicity of 1,3-Dichloro-2-Propanol (1,3-DCP; α,γ-Dichlorohydrin) . Reproductive and Cancer Hazard Assessment Branch Office of Environmental Health Hazard Assessment, California Environmental Protection Agency . June 2010.
4. Web site: List of Classifications . International Agency for Research on Cancer.
5. 10.1021/acs.jafc.6b05051. 28064506. Simultaneous Analysis of 3-MCPD and 1,3-DCP in Asian Style Sauces Using QuEChERS Extraction and Gas Chromatography–Triple Quadrupole Mass Spectrometry. Journal of Agricultural and Food Chemistry. 65. 4. 981–985. 2017. Genualdi. Susan. Nyman. Patricia. Dejager. Lowri. 5450852.
6. 10.1080/02652030110098580. 11962691. Determination of 1,3-dichloropropanol in soy sauces by automated headspace gas chromatography-mass spectrometry. Food Additives and Contaminants. 19. 4. 343–349. 2002. Crews. C. Lebrun. G. Brereton. P. A. 28748623.
7. 10.1111/1541-4337.12120. 3-Chloropropane-1,2-diol (3-MCPD) in Soy Sauce: A Review on the Formation, Reduction, and Detection of This Potential Carcinogen. Comprehensive Reviews in Food Science and Food Safety. 14. 48–66. 2015. Lee. Bai Qin. Khor. Sook Mei. 1. 33401813.