Distearoylphosphatidylcholine Explained

Distearoylphosphatidylcholine is a phosphatidylcholine, a kind of phospholipid. It is a natural constituent of cell membranes, eg. soybean phosphatidylcholines are mostly different 18-carbon phosphatidylcholines (including minority of saturated DSPC), and their hydrogenation results in 85% DSPC.[1] It can be used to prepare lipid nanoparticles which are used in mRNA vaccines,[2] [3] In particular, it forms part of the drug delivery system for the Moderna and Pfizer COVID-19 vaccines.[4] [5]

See also

Moderna COVID-19 vaccine nanoparticle ingredients
Others

Notes and References

  1. van Hoogevest P, Wendel A . The use of natural and synthetic phospholipids as pharmaceutical excipients . The European Journal of Lipid Science and Technology . 116 . 9 . 1088–1107 . 2014 . 25400504 . 4207189 . 10.1002/ejlt.201400219 .
  2. Puri A, Loomis K, Smith B, Lee JH, Yavlovich A, Heldman E, Blumenthal R . Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic . Critical Reviews in Therapeutic Drug Carrier Systems . 26 . 6 . 523–80 . 2009 . 20402623 . 2885142 . 10.1615/critrevtherdrugcarriersyst.v26.i6.10 .
  3. Salvatori G, Luberto L, and Marra E. SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines.. 18 . 2020 . 10.1186/s12967-020-02392-y . Journal of Translational Medicine. 1. 222. 32493510. 7268185. free.
  4. Web site: Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older . Centers for Disease Control and Prevention (CDC).
  5. Web site: Pfizer-BioNTech COVID-19 Vaccine EUA Fact Sheet for Recipients and Caregivers . 29 June 2022 . Food and Drug Administration (FDA).

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