1,2-α-L-fucosidase explained

1,2-α-L-Fucosidase
Ec Number:	3.2.1.63
Cas Number:	37288-45-2
Go Code:	0047513

The enzyme 1,2-α-L-fucosidase catalyzes the following chemical reaction:

methyl-2-α-L-fucopyranosyl-β-D-galactoside + HO

\rightleftharpoons L-fucose + methyl β-D-galactoside

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is 2-α-L-fucopyranosyl-β-D-galactoside fucohydrolase. Other names in common use include almond emulsin fucosidase, and α-(1→2)-L-fucosidase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• Bahl OP . 1970 . Glycosidases of Aspergillus niger. II. Purification and general properties of 1,2-α-L-fucosidase . J. Biol. Chem. . 245 . 299 - 304 . 5460888 . 2 .
• Ogata-Arakawa M, Muramatsu T, Kobata A . 1977 . α-L-Fucosidases from almond emulsin: characterization of the two enzymes with different specificities . Arch. Biochem. Biophys. . 181 . 353 - 8 . 18111 . 10.1016/0003-9861(77)90514-8 . 1 .
• Reglero A, Cabezas JA . 1976 . Glycosidases of molluscs. Purification and properties of α-L-fucosidase from Chamelea gallina L . Eur. J. Biochem. . 66 . 379 - 87 . 7458 . 10.1111/j.1432-1033.1976.tb10527.x . 2 . free .