Symmetrical dimethylhydrazine explained

Symmetrical dimethylhydrazine, or 1,2-dimethylhydrazine, is the organic compound with the formula (CH3NH)2. It is one of the two isomers of dimethylhydrazine. Both isomers are colorless liquids at room temperature, with properties similar to those of methylamines. Symmetrical dimethylhydrazine is a potent carcinogen that acts as a DNA methylating agent.[1] [2] The compound has no commercial value, in contrast to its isomer unsymmetrical dimethylhydrazine (1,1-dimethylhydrazine), which is used as a rocket fuel.[3]

It is used to induce colon tumors in experimental animals—particularly mice and feline cell samples.[4] [5]

Notes and References

  1. Salehi . Alireza . Hosseini . Seyed Mohammad . Kazemi . Sohrab . 2022-06-23 . Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats . BioMed Research International . en . 2022 . e8497562 . 10.1155/2022/8497562 . 2314-6133 . 9246617 . 35782078 . free .
  2. Valaei . Amirhasan . Azadeh . Fatemeh . Mostafavi Niaki . Seyedeh Talayeh . Salehi . Alireza . Shakib Khoob . Maede . Mirebrahimi . Seyed Hesam odin . Kazemi . Sohrab . Hosseini . Seyed Mohammad . 2022-10-10 . Antioxidant and Anticancer Potentials of the Olive and Sesame Mixture against Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats . BioMed Research International . en . 2022 . e5440773 . 10.1155/2022/5440773 . 2314-6133 . 9576397 . 36262974 . free .
  3. Human health perspective of environmental exposure to hydrazines: A review. Gangadhar Choudhary, Hugh Hansen. August 1998. Chemosphere. 37. 5. 801–843. 10.1016/S0045-6535(98)00088-5. 9717244. 1998Chmsp..37..801C.
  4. Cruse . J. P. . Lewin . M. R. . Ferulano . G. P. . Clark . C. G. . December 1978 . Co-carcinogenic effects of dietary cholesterol in experimental colon cancer . Nature . 276 . 5690 . 822–5 . 723955 . 10.1038/276822a0 . 1978Natur.276..822C . 4303843 .
  5. Wijnands . M.V.W. . April 1999 . A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds . Carcinogenesis . 20 . 4 . 651–6 . 10223195 . 10.1093/carcin/20.4.651 .

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