Rs1800955 Explained
| Rsid: | 1800955 |
| Name 1: | C-521T |
| Name 2: | -521C/T |
| Gene: | DRD4 |
| Region: | Promoter |
| Alfred: | SI000215I |
| Szgene Geneid: | 94 |
| Szgene Polyid: | 801 |
| Chromosome: | 11 |
In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP).It is located in the promoter region of the DRD4 gene.This gene codes for the dopamine receptor D4.
Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder.[1]
The SNP has been investigated with respect to novelty seeking, - a personality trait that may be measured with the Temperament and Character Inventory.[2] [3] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.[4]
References
Other
- Table 4 from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"
Notes and References
- Web site: Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955 . . 2008-09-05 .
- . Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait . . 5 . 1 . 64–69 . January 2000 . 10673770 . 10.1038/sj.mp.4000563. free .
- . Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene . . 6 . 1 . 35–38 . January 2001 . 11244482 . 10.1038/sj.mp.4000832. free .
- . Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data . . 63 . 2 . 197–206 . January 2008 . 10.1016/j.biopsych.2007.04.006 . 17574217. 28997438 .
