(pyruvate dehydrogenase (acetyl-transferring))-phosphatase explained

[pyruvate dehydrogenase (lipoamide)] phosphatase
Ec Number:	3.1.3.43
Cas Number:	9073-70-5
Go Code:	0004741

The enzyme [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) catalyzes the reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + HO

\rightleftharpoons [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ . 1972 . α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart . Arch. Biochem. Biophys. . 148 . 327 - 42 . 4401694 . 10.1016/0003-9861(72)90151-8 . 2 .
• Reed LJ, Damuni Z, Merryfield ML . 1985 . Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation . Curr. Top. Cell. Regul. . Current Topics in Cellular Regulation . 27 . 41 - 9 . 10.1016/b978-0-12-152827-0.50011-6 . 3004826 . 9780121528270 .