(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase explained

(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase
Ec Number:2.1.1.247

(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase (methyltransferase 2, MT2, MT2-A, mtbA (gene)) is an enzyme with systematic name methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase.[1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M methyl-CoM + [Co(I) methylamine-specific corrinoid protein]

This enzyme contains zinc.

Notes and References

  1. Burke SA, Krzycki JA . Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine . Journal of Bacteriology . 177 . 15 . 4410–6 . August 1995 . 7635826 . 177191 .
  2. LeClerc GM, Grahame DA . Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression . The Journal of Biological Chemistry . 271 . 31 . 18725–31 . August 1996 . 8702528 . 10.1074/jbc.271.31.18725 . free .
  3. Ferguson DJ, Krzycki JA . Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri . Journal of Bacteriology . 179 . 3 . 846–52 . February 1997 . 9006042 . 178769 . 10.1128/jb.179.3.846-852.1997 .
  4. Burke SA, Lo SL, Krzycki JA . Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine . Journal of Bacteriology . 180 . 13 . 3432–40 . July 1998 . 9642198 . 107300 .
  5. Ferguson DJ, Gorlatova N, Grahame DA, Krzycki JA . Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri . The Journal of Biological Chemistry . 275 . 37 . 29053–60 . September 2000 . 10852929 . 10.1074/jbc.m910218199 . free .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.