(hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase explained

[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
Ec Number:	3.1.3.47
Cas Number:	73507-97-8
Go Code:	0047384

The enzyme [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC 3.1.3.47) catalyzes the reaction

[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + HO

\rightleftharpoons [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.

References

• Gil G, Hegardt FG . 1982 . Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver . Arch. Biochem. Biophys. . 214 . 192 - 8 . 6282220 . 10.1016/0003-9861(82)90022-4 . 1 .
• Gil G, Sitges M, Hegardt FG . 1981 . Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases . Biochim. Biophys. Acta . 663 . 211 - 21 . 6260210 . 1 . 10.1016/0005-2760(81)90207-1.