(deoxy)nucleoside-phosphate kinase explained

(deoxy)nucleoside-phosphate kinase
Ec Number:	2.7.4.13
Cas Number:	37278-20-9
Go Code:	0047507

In enzymology, a (deoxy)nucleoside-phosphate kinase is an enzyme that catalyzes the chemical reaction

ATP + deoxynucleoside phosphate

\rightleftharpoons ADP + deoxynucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate.^[1]

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

Notes and References

1. BESSMAN MJ, HERRIOTT ST, ORR MJ . 1965 . THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5 . J. Biol. Chem. . 240 . 439 - 45 . 14253449 .