(d)CMP kinase explained

(d)CMP kinase
Ec Number:	2.7.4.25

(d)CMP kinase (prokaryotic cytidylate kinase, deoxycytidylate kinase, dCMP kinase, deoxycytidine monophosphokinase) is an enzyme with systematic name ATP:(d)CMP phosphotransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

ATP + (d)CMP

\rightleftharpoons ADP + (d)CDP

The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP).

Notes and References

1. Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM . Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme . Journal of Molecular Biology . 315 . 5 . 1099–110 . February 2002 . 11827479 . 10.1006/jmbi.2001.5286 .
2. Thum C, Schneider CZ, Palma MS, Santos DS, Basso LA . The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP . Journal of Bacteriology . 191 . 8 . 2884–7 . April 2009 . 19181797 . 2668428 . 10.1128/jb.01337-08 .