(carboxyethyl)arginine beta-lactam-synthase explained

(Carboxyethyl)arginine β-lactam-synthase
Ec Number:	6.3.3.4
Cas Number:	68247-54-1
Go Code:	0034027

In enzymology, a (carboxyethyl)arginine β-lactam-synthase is an enzyme that catalyzes the chemical reaction

ATP + L-N-(2-carboxyethyl)arginine

\rightleftharpoons AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

Further reading

• Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI . Edward I. Solomon . 2001 . Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities . . 123 . 7388 - 98 . 11472170 . 10.1021/ja004025+. 30 .
• Townsend CA . 2002 . New reactions in clavulanic acid biosynthesis . Curr. Opin. Chem. Biol. . 6 . 583 - 9 . 12413541 . 10.1016/S1367-5931(02)00392-7 . 5 .
• Bachmann BO, Li R, Townsend CA . 1998 . β-Lactam synthetase: A new biosynthetic enzyme . . 95 . 9082 - 6 . 9689037 . 10.1073/pnas.95.16.9082 . 16 . 21295 . 1998PNAS...95.9082B . free .