(acyl-carrier-protein) phosphodiesterase explained

[acyl-carrier-protein] phosphodiesterase
Ec Number:	3.1.4.14
Cas Number:	37288-21-4
Go Code:	0008770

The enzyme [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) catalyzes the reaction

holo-[acyl-carrier-protein] + HO

\rightleftharpoons 4-phosphopantetheine + apo-[acyl-carrier-protein]

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is holo-[acyl-carrier-protein] 4-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and CoA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Sobhy C . 1979 . Regulation of fatty acid synthetase activity. The 4-phosphopantetheine hydrolase of rat liver . J. Biol. Chem. . 254 . 8561 - 6 . 224058 . 17 .
• Vagelos PR, Larrabes AR . 1967 . Acyl carrier protein. IX. Acyl carrier protein hydrolase . J. Biol. Chem. . 242 . 1776 - 81 . 4290442 . 8 .
• Thomas J, Cronan JE . 2005 . The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization . J. Biol. Chem. . 280 . 34675 - 83 . 16107329 . 10.1074/jbc.M505736200 . 41 . free .