(Z)-4-Amino-2-butenoic acid explained

(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABA-ρ (previously known as GABA) subtype.[1] [2] [3]

Notes and References

  1. Qian . H . Dowling . JE . Selective agonists for GABAC receptors . Trends in Neurosciences . 19 . 5 . 190 . 1996 . 8723205 . 10.1016/0166-2236(96)85451-8. 208792634 .
  2. Duke . RK . Chebib . M . Balcar . VJ . Allan . RD . Mewett . KN . Johnston . GA . (+)- and (−)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors . Journal of Neurochemistry . 75 . 6 . 2602–10 . 2000 . 11080214 . 10.1046/j.1471-4159.2000.0752602.x. free .
  3. Reis . GM . Duarte . ID . Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid . Life Sciences . 80 . 14 . 1268–73 . 2007 . 17316706 . 10.1016/j.lfs.2006.12.015 .

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