(Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase explained

(Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase
Ec Number:	2.4.1.229

In enzymology, a [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

UDP-N-acetylglucosamine + [Skp{{sub|1}}-protein]-hydroxyproline

\rightleftharpoons UDP + [Skp{{sub|1}}-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline

Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and Skp1-protein-hydroxyproline, whereas its two products are UDP and Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase. Other names in common use include Skp1-HyPro GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide, GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, and UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase.

References

• CM . 2002 . Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of dictyostelium . J. Biol. Chem. . 277 . 46328 - 37 . 12244115 . 10.1074/jbc.M208024200 . Morris . HR . Panico . M . Paxton . T . Dell . A . Kaplan . L . West . CM . 48 . free .
• Teng-Umnuay P, van der Wel H, West CM . 1999 . Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium . J. Biol. Chem. . 274 . 36392 - 402 . 10593934 . 10.1074/jbc.274.51.36392 . 51 . free .
• West CM, van der Wel H, Gaucher EA . 2002 . Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins . Glycobiology . 12 . 17R - 27R . 11886837 . 10.1093/glycob/12.2.17R . 2 . free .