(S)-norcoclaurine synthase explained
| (S)-norcoclaurine synthase |
| Ec Number: | 4.2.1.78 |
| Cas Number: | 79122-01-3 |
| Go Code: | 0050474 |
The enzyme (S)-norcoclaurine synthase catalyzes the chemical reaction
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (Dopamine)
(
S)-
norcoclaurine + HO
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (''S'')-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in benzylisoquinoline alkaloid biosynthesis.
References
- Stadler R, Zenk MH . 1990 . A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline . Liebigs Ann. . Chem. . 555 - 562 . 10.1002/jlac.1990199001104 .
- Stadler R, Kutchan TM, Zenk MH . 1989 . (S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis . . 28 . 1083 - 1086 . 10.1016/0031-9422(89)80187-6 . 4 .
- Samanani N, Facchini PJ . 2002 . Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants . J. Biol. Chem. . 277 . 33878 - 83 . 12107162 . 10.1074/jbc.M203051200 . 37 . free .
