(RS)-MCPG explained

(RS)-MCPG is a phenylglycine derivative and a non-selective antagonist of group I and II metabotropic glutamate receptors (mGluRs). It has been used in long-term potentiation (LTP) as well as long-term depression (LTD) research and proved that certain LTP and LTD pathways depend on mGluRs.[1] [2] Its full chemical name is (RS)-α-methyl-4-carboxyphenylglycine. It appears as a white solid and its molecular weight is 209.2 Da. Its molecular formula is C10H11NO4.[3]

Notes and References

  1. Bortolotto ZA, Bashir ZI, Davies CH, Collingridge GL . A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation . Nature . 368 . 6473 . 740–3 . April 1994 . 8152485 . 10.1038/368740a0 . 1994Natur.368..740B . 4255573 .
  2. Otani S, Connor JA . Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus . The Journal of Physiology . 511 (Pt 3) . 3 . 761–70 . September 1998 . 9714858 . 2231146 . 10.1111/j.1469-7793.1998.761bg.x .
  3. Web site: (RS)-MCPG . Hello Bio .

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