(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase explained

(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Ec Number:	2.1.1.115
Cas Number:	132084-82-3
Go Code:	0030776

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase is an enzyme that catalyzes the chemical reaction:^[1]

S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

\rightleftharpoons S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolineThis enzyme participates in alkaloid biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase.

Notes and References

1. Frenzel T, Zenk MH . 1990 . Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures . . 29 . 3491 - 3497 . 10.1016/0031-9422(90)85263-F . 11 .