(RNA-polymerase)-subunit kinase explained

RNA polymerase subunit kinase
Ec Number:2.7.11.23
Cas Number:122097-00-1
Go Code:0008353

In enzymology, an [RNA-polymerase]-subunit kinase is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase]

\rightleftharpoons

ADP + phospho-[DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and DNA-directed RNA polymerase, whereas its two products are ADP and phospho-DNA-directed RNA polymerase.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.

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