(R)-p-Isothiocyanatobenzoylecgonine methyl ester explained

(R)-p-Isothiocyanatobenzoylecgonine methyl ester (p-ISOCOC) is a cocaine analogue and irreversible (covalent) binding inhibitor of the cocaine receptor, as well as irreversible blocker of dopamine uptake by DAT (the latter being unlike its C3 homologue m-Isococ). p-Isococ also blocks the high-affinity cocaine site in preference to the low-affinity site.^[1]

See also

• RTI-76, covalent binding phenyltropane
• 4'-Fluorococaine

References

1. Carroll FI, Lewin AH, Boja JW, Kuhar MJ . Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter . Journal of Medicinal Chemistry . 35 . 6 . 969–81 . March 1992 . 1552510 . 10.1021/jm00084a001 .